The unique luminal staining pattern of cytokeratin 5/6 in adenoid cystic carcinoma of the breast may aid in differentiating it from its mimickers. Adenoid cystic carcinoma (Ad. CC) of the breast is an uncommon but distinct neoplasm composed of a dual cell population polarized around true glandular (luminal) spaces and pseudolumina. The aim of this study was to clarify whether various immunohistochemical markers (CK7, EMA, CD1. CD1. 0, S1. 00, CK5/6, CK1. IV collagen) can distinguish between the two cell types in classical Ad. CC (n = 1. 4) and in collagenous spherulosis (n = 5).
The sensitivity and specificity of these 1. The most sensitive and specific markers for luminal cells in Ad. CC were CK7 and EMA; those for abluminal cells were type IV collagen, p. CD1. 0 and S1. 00 did not act as abluminal markers in Ad. CC. CK5/6, one of the basal/myoepithelial markers, was expressed more frequently in luminal than in abluminal cells of Ad. Clinical Guidelines, Diagnosis and Treatment Manuals, Handbooks, Clinical Textbooks, Treatment Protocols, etc.Adenoid cystic carcinoma (AdCC) of the breast is an uncommon but distinct neoplasm composed of a dual cell population polarized around true glandular (luminal) spaces. CC. Thus, CK5/6 immunostaining resulted in a reverse expression pattern, analogous to what we recently documented in clear cells in mammary adenomyoepithelioma. In conclusion, compared with myoepithelial/abluminal cells of normal breast or collagenous spherulosis, the neoplastic abluminal cells of classical Ad. CC are characterized by enhanced vimentin and attenuated CD1. S1. 00. Furthermore, the luminal cells of Ad. CC show a unique aberrant staining pattern for CK5/6 that may aid in the differential diagnosis. Keywords. Adenoid cystic carcinoma Myoepithelial cells Cytokeratin 5/6 Vimentin Collagenous spherulosis.
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November 2017
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